Research has been underway on the effect of Cannabidiol or CBD on bone healing and growth. Scientists are unanimous on the view that CBD can pace up the process of healing of broken bones by the body and make them stronger. In the form of a catalyst for skeletal reconstruction, CBD may offer more insight into the effective therapy of different hard-to-treat bone disorders like osteoporosis and osteomyelitis. Osteomyelitis is a serious though rare condition which leads to an infection of the bone and CBD can prove useful for its therapy. Moreover, CBD incorporates various other benefits that do not concern skeletal structures which may be effective in mitigating different symptoms that accompany bone degradation disorders also.
What Constitutes Osteomyelitis?
Osteomyelitis comprises an inflammation and infection of the bone marrow or the bone. It can occur if a fungal or bacterial infection reaches the bone tissue from the bloodstream, on account of injury or surgery. Nearly 80% of cases result from an open wound. Symptoms comprise muscle spasms and deep pain in the inflammation region, and fever.
Bone infections generally impact the long bones in the upper arm and leg, the pelvis and the spine. Previously, osteomyelitis therapy was difficult, but presently, aggressive treatment can frequently secure the infected bone and arrest the spread of infection.
Smokers and people with chronic health conditions, like kidney failure or diabetes, have a greater risk of contracting osteomyelitis. People with diabetes may acquire osteomyelitis in their feet if they possess foot ulcers.
How Is Osteomyelitis Caused?
Various ways can lead to the development of the bone infection of osteomyelitis. Bacteria may move along the bloodstream (bacteremia) and extend to the bone, leading to infection (hematogenous osteomyelitis). This frequently happens if the patient carries an infectious disease somewhere else within the body, like pneumonia, a urinary tract infection, or an abscessed tooth that spreads along with the blood to the bone.
Osteomyelitis can also be caused by an open wound from a trauma (post-traumatic wound). This is most common with underlying peripheral neuropathy, peripheral vascular disease, or diabetes mellitus. In an open fracture or compound fracture, bacteria may reach the bone that ruptures the skin. This raises the risk of osteomyelitis.
A late surgery or injection in or near a bone can also reveal the bone to bacteria and cause periostitis, an infection affecting the surface membrane of the bone. This can deteriorate and impact the entire bone, resulting in osteomyelitis.
The most popular types of bacteria that lead to osteomyelitis comprise Staphylococcus (including the methicillin-resistant Staphylococcus aureus or MRSA), Enterobacteriaceae, and Pseudomonas. Less popularly, gram-negative bacteria result in osteomyelitis.
Patients having conditions or consuming medications that enfeeble their immune system are at greater risk of acquiring osteomyelitis. Risk factors comprise cancer, sickle cell disease, chronic steroid usage, human immunodeficiency virus (HIV), hemodialysis, diabetes, infants, intravenous drug users, and the aged.
Symptoms Of Osteomyelitis
Redness, pain, and swelling can be an indication of a bone infection. The symptoms of osteomyelitis rest on the type.
They generally comprise:
- Pain that may be acute, and swelling, tenderness, and redness in the affected region
- Irritability, fatigue, or lethargy
- Fever, sweating, and chills
- Drainage by an open wound close to the infection site or across the skin
Some other symptoms may include swelling of the ankles, legs, and feet, and alterations in the pattern of walking, for instance, a limp.
Chronic osteomyelitis symptoms are not always clear, or they might match the symptoms of an injury.
How CBD Is Effective For Osteomyelitis
CBD can aid to mitigate the symptoms of Osteomyelitis like bone loss, pain, inflammation, and bacterial infection to offer symptomatic relief. CBD acts in the following ways.
Promotes Bone Healing
Bone formation is activated through cannabinoid receptors, which indicate that cannabinoid medications like CBD may be an effective therapy for fractures and bone diseases. Israeli researchers had previously discovered that the skeleton is controlled by cannabinoids and cannabinoid receptors in the body stimulate bone formation that restricts bone loss. The findings indicated that CBD may be an effective treatment for bone-based diseases like osteoporosis and osteomyelitis.
It has been found that CBD by itself strengthens bones while healing, advancing the collagenous matrix maturation, which offers the basis for fresh bone tissue mineralization. Upon treatment with CBD, the treated bone will be more difficult to split in the future.
CBD has been shown by recent research to accelerate bone healing, stop diseases and slow bone degeneration. It can assist with osteomyelitis pain control and osteoporosis. CB2 receptors have been reported to play a role in balancing bone metabolism, thereby slowing age-based bone decay.
Heals Broken Bones
Generally, when your bone is broken, your body will link the two broken pieces by a cartilage growth termed fracture callus. A CBD injection in rats aided them to heal a broken femur quicker than their untreated partners, with the boneless probable to break again as the fracture callus was much stronger.
CBD also aids to obstruct the enzyme that leads to bone breakdown. These fatty acid amides are disintegrated by an enzyme known as FAAH – which can lead to osteoporosis, and potentially to cascade failure of different skeletal conditions. CBD obstructs the FAAH enzyme, stopping it from forming the compounds that disintegrate the bone cells.
Helps To Fight Inflammation
CBD can play a therapeutic role in the matter of inflammation. The molecule may act to combat inflammation and its associated oxidative stress in different ways, like exerting an immunosuppressive effect on macrophages and microglial cells, which play a role in swelling and immunity.
CBD has also shown to significantly reduce chronic inflammatory pain by probably stimulating glycine receptors. The powerful anti-inflammatory effects of cannabinoids are imparted by induction of apoptosis, inhibition of cell multiplication, suppression of cytokine production and induction of T-regulatory cells.
Effective As A Pain Reliever
The analgesic property of CBD helps to alleviate pain caused by osteomyelitis. For instance, CBD stops the body from absorbing Anandamide, a compound associated with pain regulation. Thereby, CBD can reduce the amount of pain and inflammation. CBD also attaches to TRPV1 receptors that act as ion channels and is recognized for mediating pain sensitivity, swelling and body temperature.
Functions As An Antibacterial Agent
CBD generates potent antiviral, antifungal, and antibacterial effects. This cannabinoid kills staphylococci and streptococci. According to a research CBD kills the methicillin-resistant strains of Staphylococcus aureus or MRSA that causes osteomyelitis. CBD is also shown to alter bacterial cell wall, similar to conventional antibiotics. This prevents their development and propagation.
Conclusion On CBD For Osteomyelitis
Though CBD should not be regarded as a blanket therapy for all ailments and disorders, its advantages in managing symptoms are awesomely significant. Tissue repair and skeletal regeneration are just the tip of the iceberg in the therapeutic advantages offered by CBD, and continued research may reveal means to treat even better some of the most notorious human health problems like osteomyelitis.